Canvax Human DIABLO (Diablo Homolog, Mitochondrial), 6xHis-GST tags PR0402

Human DIABLO (Diablo Homolog, Mitochondrial), 6xHis-GST tags, high quality recombinant protein with proven performance in elisa, wb, ab production or protein array

Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.

Main Features:

Highest purity: free of interferences from other proteins or contaminants. Convenient: available in different sizes and tags. Cost avoidance: dry ice free of charge.

Includes: Includes for 50 µg: - 50 µg Recombinant Protein - Dry ice

Applications: ELISA. Western Blot. Antibody Production. Protein array.